Submit processed tissue block or tissue section mounted on a charged, unstained slide
AHL - Immunohistochemistry
Days Set Up:
Mo - Fr
1 - 2 days
If requested, an interpretive report will be provided All IHC stains will include a positive control tissue
Collection/ Processing Details:
P53 is a transcription factor that regulates cell growth and inhibits cells from entering S-phase
P53 is a DNA-binding phosphoprotein coded for by a tumor suppressor gene located on the short arm of chromosome 17
Mutations of p53 or functional inactivation with intact p53 genes are common in many cancers, leading to loss of normal growth regulation
Although p53 is present in small amounts in normal cells (not usually detected by routine immunohistochemistry), mutations resulting in a prolonged half-lives lead to accumulations that are detected by immunohistochemistry
Over-expression is associated with a poor prognosis in many cancers
P53 over-expression is present in many different malignancies, such as colon, stomach, bladder, breast, lung, testes, melanomas, sarcomas, etc.
Bartek J et al: Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. Oncogene 1991; 6: 1699-703.