Allina Health Laboratory a part of Abbott Northwestern Hospital



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Test Name:Pepsinogen I
Test Number:994
Collect:3.0 mL serum - SST
Minimum Volume:1.0 mL
Alternate Collect:3.0 mL EDTA plasma - lavender
Container:LabCorp screw-capped purple frozen plastic transport tube labelled as serum or EDTA plasma
Processing:Spin, separate and freeze immediately
Transport/Stability:Frozen (strict) - 365 days
Refrigerated - NO
Ambient - NO
Alternate Names:PG1

Performing Lab:Interscience Institute ( ) via LabCorp (276045); R-NX
Days Set Up:Varies, 1 per week
Expected TAT:7 days
Ref. Ranges:An interpretive report will be provided
Processing Details:
Useful for:
Pepsinogen I is produced primarily in the Oxyntic gland mucosa of the stomach. It is secreted mainly into the gastric lumen and into circulation. Pepsinogen I has little or no biological activity but in acid is converted to the active enzyme Pepsin which exhibits proteolytic actions. Pepsinogen I is cleared by the kidney and secreted into the urine. Patients with pernicious anemia and gastrectomized patients have low to non-detectable levels of Pepsinogen I. Pepsinogen I levels are slightly elevated in gastric ulcer, higher in gastroduodenal ulcer and significantly elevated in duodenal ulcer. Patients with Zollinger-Ellison's syndrome exhibit greatly elevated levels. Pepsinogen I has been shown to correlate with presence of genetic duodenal ulcer, and has been used as a subclinical marker of increased risk for stomach cancer.

Patient preparation
Patient should be fasting 10-12 hours prior to collection of specimen. Antacids or other medications affecting stomach acidity or gastrointestinal motility should be discontinued, if possible, for at least 48 hours prior to collection.

Serum or plasma must be separated from cells within 45 minutes of sample collection.
Method:Direct Radioimmunoassay (Direct RIA)
CPT Codes:83519
Date Created:05/04/2011
Revised Date:05/24/2019