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Test Name:Adipophilin by IHC
Test Number:12376 - Technical only; 12379 - Technical & interpretation
Collect:Formalin-fixed, paraffin embedded (FFPE) tissue block.
Container:FFPE tissue block
Processing:Submit processed tissue block or tissue section mounted on a charged, unstained slide.
Transport/Stability:Ambient (preferred)
Alternate Names:ADP
ADRP
IHC
LAB12376
LAB12379
Performing Lab:AHL – Immunohistochemistry
Days Set Up:Mo – Fr
Expected TAT:1 - 2 days
Ref. Ranges:If requested, an interpretive report will be provided
All IHC stains will include a positive control tissue
Collection/
Processing Details:



Specifications:
  • Adipophilin (ADP) is a protein present on the surface of intracellular lipid droplets
  • ADP is present in sebaceous lesions (particularly well-differentiated tumors)
Staining patterns:
  • Cytoplasmic membranous pattern of intracytoplasmic lipid globules
  • Granular staining is considered NEGATIVE for ADP
Applications:
  • This marker may be used to identify sebaceous neoplasms, including sebaceous carcinoma and sebaceoma (sensitivity is approximately 97%)
  • ADP will also stain milk fat globule membranes and lipid droplets, such as in adrenal gland (zona fasciculata), testes (Sertoli cells) and in lactating breast
  • Staining for ADP has been reported in eccrine apocrine carcinomas, xanthomatous lesions, and metastatic renal cell carcinomas (but the pattern is often granular which is considered negative for ADP
Immunostains in evaluation of possible sebaceous tumors

ADP EMA Androgen receptor BerEp4
Sebaceous carcinorma + + + (83%) -
Squamous cell carcinoma - + - (90%) - (rare +)
Sebaceoma + + +/- (50%) -
Basal cell carcinoma - - +/- (50%) + (80%)
References:
  1. Ferringer T. Immunohistochemistry in dermatopathology. Arch Pathol Lab Med. 2015;139:83-105.
  2. Ansai S et al: Sebaceous carcinoma: an immunohistochemical reappraisal. Am J Dermatopathol. 2011;33(6)579-587.

Method:Immunohistochemical staining
Microscopic examination
CPT Codes:88342 - 1st stain
88341 - each additional stain
Date Created:04/28/2017
Revised Date:10/17/2018