All IHC stains will include a positive control tissue on each slide.
FFPE tissue block
AHL - Immunohistochemistry
Days Set Up:
Mo - Fr
1 - 2 days
If requested, an interpretive report will be provided
Collection/ Processing Details:
Arginase-1 is a urea cycle metalloenzyme that is expressed in liver.
This antibody is a sensitive and specific marker that can be used to confirm hepatocellular differentiation and exclude other possible primaries.
Strong diffuse cytoplasmic staining; patchy nuclear staining can also be seen.
Arginase-1 reactivity is seen in the vast majority of well-differentiated hepatocellular carcinomas (HCC), but may be absent in poorly differentiated HCCs.
This antibody is more sensitive than HepPar-1 in identifying HCC (table 2 (2)).
This antibody is very useful with Glypican 3 in identifying scirrhous HCC (more useful than HepPar-1).
One study showed rare non-hepatic tumors with Arginase reactivity (cholangiocarcinoma and prostatic adenocarcinoma; (2)).
1. Krings G et al: Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma. Modern Pathology (2013) 26, 782–791.
2. Yan, BC et al: A New Immunohistochemical Marker of Hepatocytes and Hepatocellular Neoplasms. Am J Surg Pathol 2010;34:1147–1154).
3. Ordonez NG: Arginase-1 is a novel immunohistochemical marker of hepatocellular differentiation. Adv Anat Pathol 2014;21:285–290.