Allina Health Laboratory
a part of Abbott Northwestern Hospital
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Reference ranges/critical values
Specimen collection instructions
Arginase-1 by IHC
12376 - Technical only; 12379 - Technical & interpretation
Formalin-fixed, paraffin embedded (FFPE) tissue block.
FFPE tissue block
Submit processed tissue block or tissue section mounted on a charged, unstained slide.
AHL - Immunohistochemistry
Days Set Up:
Mo - Fr
1 - 2 days
If requested, an interpretive report will be provided
All IHC stains will include a positive control tissue
Arginase-1 is a urea cycle metalloenzyme that is expressed in liver
This antibody is a sensitive and specific marker that can be used to confirm hepatocellular differentiation and exclude other possible primaries
Strong diffuse cytoplasmic staining; patchy nuclear staining can also be seen
Arginase-1 reactivity is seen in the vast majority of well-differentiated hepatocellular carcinomas (HCC), but may be absent in poorly differentiated HCCs
This antibody is more sensitive than HepPar-1 in identifying HCC (table 2
This antibody is very useful with Glypican 3 in identifying scirrhous HCC (more useful than HepPar-1)
One study showed rare non-hepatic tumors with Arginase reactivity (cholangiocarcinoma and prostatic adenocarcinoma;
Krings G et al: Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma. Modern Pathology (2013) 26, 782–791.
Yan, BC et al: A New Immunohistochemical Marker of Hepatocytes and Hepatocellular Neoplasms. Am J Surg Pathol 2010;34:1147–1154).
Ordonez NG: Arginase-1 is a novel immunohistochemical marker of hepatocellular differentiation. Adv Anat Pathol 2014;21:285–290.
88342 - 1
88341 - each additional stain