Allina Health Laboratory a part of Abbott Northwestern Hospital



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Test Name:Prostate specific antigen by IHC
Test Number:12376 - Technical only; 12379 - Technical & Interpretation
Collect:Formalin-fixed, paraffin embedded (FFPE) tissue block
Container:FFPE tissue block
Processing:Submit processed tissue block or tissue section mounted on a charged, unstained slide
Transport/Stability:Ambient (preferred)
Alternate Names:PSA
Performing Lab:AHL - Immunohistochemistry
Days Set Up:Mo - Fr
Expected TAT:1 - 2 days
Ref. Ranges:If requested, an interpretive report will be provided
All IHC stains will include a positive control tissue
Processing Details:

  • PSA is a glycoprotein found in normal and neoplastic secretory and ductal prostatic epithelium
Staining pattern:
  • Cytoplasmic based staining.
  • PSA is expressed by >99% of prostatic carcinomas (although poorly differentiated prostatic carcinomas may express this antigen weakly and/or focally)
  • PSA is a very durable antigen, even with prolonged formalin fixation
  • In vast majority of cases, prostatic acid phosphatase is not needed with PSA. However, we use prostatic acid phosphatase in weakly suspiciously PSA positive or PSA negative tumors in which prostatic origin is strongly suspected.

Method:Immunohistochemical staining
Microscopic examination
CPT Codes:88342 - 1st stain
88341 - each additional stain
Date Created:08/08/2017
Revised Date:10/19/2018