Submit processed tissue block or tissue section mounted on a charged, unstained slide
AHL - Immunohistochemistry
Days Set Up:
Mo - Fr
1 - 2 days
If requested, an interpretive report will be provided All IHC stains will include a positive control tissue
Collection/ Processing Details:
Antibody to VP1 and VP2 capsid proteins of parvovirus B19 purified from human plasma
Cytoplasmic and/or nuclear
Parvovirus is responsible for up to 10% of all non-malformed fetal deaths occurring between 10 and 24 weeks of gestation.1
Fetuses dying of this infection may or may not be hydropic. Antibody usefulness has been documented even in cases of extreme autolysis
Parvovirus B19 can infect and lyse erythroid precursors causing severe anemia in patients with immunodeficiency and transient aplastic crisis in patients with chronic hemolytic anemia2
Characteristic nuclear inclusions (Lantern cells) can be difficult to visualize
Parvovirus B19 has been implicated in certain viral exanthems including Fifths disease (erythema infectiosum) and papular purpuric gloves and socks syndrome (PPGSS). Staining can be demonstrated in infected dermal endothelial cells, keratinocytes and sweat glands3
Parvovirus B19 has been reported to cause hemophagocytic syndrome and lymph node changes resembling histiocytic necrotizing lymphadenitis (Kikuchi's disease)
Wright C, et al: Fetal Pathology in Intrauterine Death due to Parvovirus B19 infection. British J. AP, Feb 1996, Vol 103, pp 133-136.
Liu W, et al: Human Parvovirus B19 in Bone marrows from Adults with Acquired Immunodeficiency Syndrome: A comparative Antibody Using In Situ Hybridization and Immunohistochemistry. Human Pathology 28(7)760-6, July 1997.
Aractingi S. et al: Immunohistochemical and Virological study of skin in the papular purpuric gloves and socks syndrome. British J. H Derm. 135(4):599-602, Oct, 1996.
Yuen Y et al: Parvovirus B19 Associated Hemophagocytic Syndrome with Lymphadenopathy resembling histiocytic necrotizing lymphadenitis (Kikuchi's disease). British J. of NEM. 96(4):868-71, 1997 March.