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Test Name:P2Y12 inhibition
Test Number:8816
Collect:Kit with instructions & tubes
Aspirin Therapy and P2Y12 collection kit
Alternate Collect:None
Container:Aspirin Therapy and P2Y12 collection kit
Processing:DO NOT SPIN - Submit entire tube(s)
Hospital Draw - hand deliver to Lab; DO NOT send thru Pneumatic Tube System (PTS).
Transport/Stability:Ambient - 3 hours
Refrigerated - NO
Frozen - NO
Alternate Names:Clopidogrel (Plavix)
Platelet Inhibition
VerifyNow
P2Y
LAB8816
Performing Lab:AHL - Coagulation; W
Abbott Northwestern; Mercy & United
Days Set Up:Daily - 24 hours
Expected TAT:1 hour
Ref. Ranges:P2Y12 Reaction Units (RU):
Patients on P2Y12 Inhibition Therapy results: <208 PRU
Patients Not on P2Y12 Inhibitor medications: 180-376 PRU
Collection/
Processing Details:
Direct venipuncture collection

1. Using a 21 gauge needle or larger (butterfly is acceptable), collect tubes in the following order:
- 1 clear top Vacutainer tube - partial fill 3 ml draw
- 3 Blue Greiner tubes - These are partial fill 2 mL draw tubes. Fill exactly to the black arrow on the tube; do not over or under fill.
- 1 lavender top tube.
2. Gently invert each tube 5 times.
3. Additional tubes may be collected after these tubes have been collected.

Line draw collection

1. Discard the first 5 mL of blood from the line.
2. Ensure the catheter is free of clots.
3. Immediately transfer blood in the following order:
- 1 clear top Vacutainer tube - partial fill 3 mL draw
- 3 blue Greiner tubes - These are partial fill 2 mL draw tubes. Fill exactly to the black arrow on the tube; do not over or under fill.
- 1 lavender top tube
4. Gently invert each tube 5 times.
5. Additional tubes may be collected after these tubes have been collected.
Method:The VerifyNow point-of-care device is available for monitoring patients on anti-P2Y12 therapy (clopidogrel and prasugrel). The extent of ADP-induced platelet aggregation is recorded as the Platelet Reactivity Unit (PRU) value, which is diminished by thienopyridine agents that block the P2Y12 ADP receptor.
CPT Codes:85576
Supply Connection:Aspirin Therapy and P2Y12 collection kit
Date Created:11/14/2011
Revised Date:08/23/2018