All IHC stains will include a positive control tissue on each slide.
FFPE tissue block
Submit processed tissue block
Serum Amyloid A
AHL - Immunohistochemistry
Days Set Up:
Mo - Fr
1 - 2 days
If requested, an interpretive report will be provided
Collection/ Processing Details:
This antibody labels amyloid A (AA) in tissues and can be used to classify AA-amyloidosis.
This antibody does not react with other amyloid types, such as Alzheimer’s amyloid plaques.
SAA can be used in a panel with glutamine synthetase and beta catenin to help differentiate between hepatic adenomas (HA) and focal nodular hyperplasia (FNH).
Strong cytoplasmic staining.
Most inflammatory HAs show strong SAA staining, which can be patchy or diffuse (>90%).
SAA is negative in most (83%) of FNH cases (rare cases show patchy or diffuse staining)
1. Linke RP: Monoclonal antibodies against amyloid fibril protein AA. Production, specificity and use for immunohistochemical localization and classification of AA-type amyloidosis. J Histochem Cytochem 1984;32:322-8.
2. Shafizadeh N et al: Diagnosis of well-differentiated hepatocellular lesions: role of immunohistochemistry and other ancillary techniques. Adv Anat Pathol 2011;18:438-445).
3. Joseph NM et al: Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma. Modern Pathology (2014) 27, 62–72; doi:10.1038/modpathol.2013.114.