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Test Name:Pernicious anemia cascade
Test Number:575
Collect:4.0 mL serum - red
Minimum Volume:2.5 mL serum - red
Alternate Collect:4.0 mL serum - SST
Container:Three (3) Mayo Screw Cap Transfer Vials, banded together
Processing:1. Divide specimen into 3 plastic vials, 1 containing 1.0 mL, 2 containing 1.5 mL each
2. Band specimens together.
3. Freeze
Transport/Stability:Frozen - 14 days
Alternate Names:PAC
Pernicious A
LAB575
Performing Lab:Mayo Clinic Laboratories (ACASM/83632); R-MM
Days Set Up:Mo - Fr and Sa
Expected TAT:1 - 4 days (Vitamin B12)
Ref. Ranges:Vitamin B12: 180 - 914 ng/L
Collection/
Processing Details:
Note: Patient should fast (8 hours) prior to collection.

Useful for:
Diagnosis of pernicious anemia
Diagnosis of vitamin B12 deficiency-associated neuropathy

Reflex Algorithm:
If B12 <150 ng/L, then Intrinsic Factor Blocking Ab (IFBA) is performed.
If IFBA is negative or indeterminate, then the Gastrin is performed.
If the B12 is 150 - 400ng/L, then the methylmalonic acid (MMA) is performed.
If the MMA is >0.4 µmol/L, then the IFBA is performed.
Method:Immunoenzymatic Assay
CPT Codes:82607 - Vit B12
82941 - Gastrin (if appropriate)
83921 - MMA (if appropriate)
86340 - IFBA (if appropriate)
Date Created:11/30/2001
Revised Date:05/21/2019