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Test Name:Progesterone receptor by IHC
Test Number:12376 - Technical only; 12379 - Technical & Interpretation
Collect:Formalin-fixed, paraffin embedded (FFPE) tissue block
Container:FFPE tissue block
Processing:Submit processed tissue block or tissue section mounted on a charged, unstained slide
Transport/Stability:Ambient (preferred)
Alternate Names:PR
IHC
LAB12376
LAB12379
Performing Lab:AHL - Immunohistochemistry
Days Set Up:Mo - Fr
Expected TAT:1 - 2 days
Ref. Ranges:If requested, an interpretive report will be provided
All IHC stains will include a positive control tissue
Collection/
Processing Details:

Specifications:
  • PR is a nuclear protein that binds progesterone hormone
  • PR expression is seen in a variety of tumors from breast or gynecologic origin
  • PR expression can also be seen in tumors of lung, stomach, thyroid, and very rarely colorectal origin (PR is less specific than ER)
Staining pattern:
  • Nuclear staining
Applications:
  • PR is used to determine if a tumor expresses estrogen receptor (i.e. for classification purposes)
  • PR positivity is used to determine if a patient would be a candidate for anti-estrogen therapy
References:
  1. Aziz DC: Quantitation of estrogen and progesterone receptors by immunocytochemical and image analyses. Am J Clin Pathol 1992; 98:105-111.
  2. Wilbur DC et al: Estrogen and progesterone receptor detection in archival formalin-fixed, paraffin-embedded tissue from breast carcinoma: A comparison of immunohistochemistry with the dextran-coated charcoal assay. Mod Pathol, 5(1), 1992.
  3. Esteban JM et al: Improvement of the quantification of estrogen and progesterone receptors in paraffin-embedded tumors by image analysis. Am J Clin Pathol, 1993; 99:32-38.
  4. Taylor CR: Paraffin section immunocytochemistry for estrogen receptor; the time has come. Cancer 77(12), 1996.

Method:Immunohistochemical staining
Microscopic examination
CPT Codes:88342 - 1st stain
88341 - each additional stain
Date Created:08/07/2017
Revised Date:10/19/2018