Formalin-fixed, paraffin-embedded tissue block; or
3 unstained glass, "positively charged" slides with 4-microns formalin-fixed, paraffin-embedded tissue
Mayo Clinical Laboratories (PDL1); R
Days Set Up:
Mo - Fr
5 - 7 days
This test will be answered as percent tumor cells positive and whether greater than or equal to 5% of immune cells express PD-L1 or not.
Collection/ Processing Details:
Identification of neoplasms expressing programmed cell death 1-ligand 1 (clone SP263)
A pathology/diagnostic report and a brief history are required.
This test has been validated for nondecalcified paraffin-embedded tissue specimens fixed in 10% neutral-buffered formalin. This assay has not been validated on tissues subjected to the decalcification process or use of alternative fixatives for bone and bone marrow specimens or cell blocks.
Immunohistochemistry (IHC) on sections of paraffin-embedded tissue using Ventana PD-L1 clone SP263. (Unpublished Mayo method)