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Test Name:PLAP by IHC
Test Number:12376 - Technical only; 12379 - Technical & Interpretation
Collect:Formalin-fixed, paraffin embedded (FFPE) tissue block
Container:FFPE tissue block
Processing:Submit processed tissue block or tissue section mounted on a charged, unstained slide
Transport/Stability:Ambient (preferred)
Alternate Names:Placental alkaline phosphatase
IHC
LAB12376
LAB12379
Performing Lab:AHL - Immunohistochemistry
Days Set Up:Mo - Fr
Expected TAT:1 - 2 days
Ref. Ranges:If requested, an interpretive report will be provided
All IHC stains will include a positive control tissue
Collection/
Processing Details:

Specifications:
  • Anti-placental alkaline phosphatase labels trophoblasts in placental tissue
Staining pattern:
  • Cytoplasmic and apical based staining
Applications:
  • Useful as a general screening marker for germ cell tumors and is positive in most
  • Classic seminomas/dysgerminomas are almost all PLAP positive
  • Spermatocytic seminomas are usually negative for PLAP
  • Embryonal carcinomas are usually (95%) positive for PLAP
  • Teratomas may or may not stain positively for PLAP
  • Endodermal sinus tumors are usually positive for PLAP
  • Choriocarcinomas typically are positive for PLAP
  • Intratubular germ cell neoplasia usually stains positively for PLAP
  • Various somatic carcinomas, including those of breast, lung, GI tract, ovary, prostate and bladder origin, have been reported to be positive for PLAP on occasion
  • PLAP positivity has also been reported in partial and complete hydatiform moles
Note:
There is cross-reactivity of this antibody with intestinal alkaline phosphatase.
Staining of striated muscle with PLAP has been observed and reported.


References:
  1. Ulbright TM: Germ Cell Neoplasms of the Testis; American Journal of Surgical Pathology; 17(11):1075-1091, 1993.

Method:Immunohistochemical staining
Microscopic examination
CPT Codes:88342 - 1st stain
88341 - each additional stain
Date Created:08/07/2017
Revised Date:10/19/2018