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Test Name:Androgen receptor image by IHC
Test Number:12376 - Technical only; 12379 - Technical & Interpretation
Collect:Formalin-fixed, paraffin embedded (FFPE) tissue block.

All IHC stains will include a positive control tissue on each slide.
Container:FFPE tissue block
Processing:
Transport/Stability:Ambient (preferred)
Alternate Names:IHC
LAB12376
LAB12379
Performing Lab:AHL – Immunohistochemistry
Days Set Up:Mo - Fr
Expected TAT:1 - 2 days
Ref. Ranges:If requested, an interpretive report will be provided
Collection/
Processing Details:

Specifications:
  • This antibody is used to identify the androgen receptor in tumor cells.

Staining patterns:
  • Strong nuclear staining

Applications:
  • Androgen receptor (AR) positivity may be used to identify patients with metastatic breast cancer who may benefit from Bicalutamide therapy (prostate cancer drug).
  • The majority of estrogen receptor positive breast cancers will also be AR positive; androgen receptors are most frequently seen in luminal A and B invasive breast cancers.
  • ARs are also seen in approximately one-third of basal-like cancers
  • AR positive, estrogen receptor negative tumors are frequently apocrine type; these may be triple negative or HER2 positive tumors.
  • Request AR IHC evaluation on breast cases using image analysis.
  • AR is also useful in the diagnosis of salivary duct carcinomas. Approximately 90% of these tumors will be AR positive, and P63 negative.

References:

1. Niemeier LA, Dabbs DJ et al: Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation. Mod Pathol (2010) 23, 205–212.
2. Collins LC et al: Androgen Receptor Expression in Breast Cancer in Relation to Molecular Phenotype: Results from the Nurses’ Health Study. Mod Pathol. 2011 July; 24(7): 924–931. doi:10.1038/modpathol.2011.54
3. Robinson JLL et al: Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1. The EMBO Journal (2011) 30, 3019–3027.

Method:Immunohistochemical staining
Microscopic examination
CPT Codes:88342 - 1st stain
88341 - each additional stain
Date Created:05/01/2017
Revised Date:10/04/2017