Allina Health Laboratory a part of Abbott Northwestern Hospital



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Test Name:Pemphigus/Pemphigoid profile I
Test Number:994
Collect:1.0 mL serum - SST
Minimum Volume:0.2 mL
Alternate Collect:1.0 mL serum - red
Container:Serum separator (SST) tube or
LabCorp 12mL plastic transport tube labelled as serum
Processing:SST – spin
Red – spin and separate
Transport/Stability:Refrigerated (preferred) - 5 days
Ambient - 48 hours
Frozen - 1 year
Alternate Names:Cutaneous Immunofluorescence
Performing Lab:IMMCO Diagnostics Inc (122) via LabCorp (806399); R-NX
Days Set Up:Mo - Fr
Expected TAT:3 - 5 days
Ref. Ranges:An interpretive report will be provided
Processing Details:
Useful for:
The detection of anti-skin (IC and BMZ) antibodies aids in the diagnosis, and sometimes prognosis, of chronic vesicular-bullous diseases including pemphigus, pemphigoid, cicatricial pemphigoid, and epidermolysis bullosa acquisita (EBA). Epithelial intercellular antibodies are diagnostic for pemphigus and occur in over 90% of patients with active forms. Because of the species specificity of intercellular antibodies, the use of the dual substrates further distinguishes the intercellular antibodies of pemphigus vulgaris and vegetans from the antibodies of pemphigus foliaceus and erythematosus. Antibodies to basement membrane antigens of stratified squamous epithelium occur in about 70% of active bullous pemphigoid, 50% of vesicular pemphigoid and EBA and 10% of cicatricial pemphigoid patients.

Method:Semi-Quantitative Indirect Immunofluorescence (IFA) Substrate: Rhesus Monkey and Guinea Pig Esophagus/NaCl Split-Skin Substrate
CPT Codes:86256 x 2
Date Created:05/24/2019
Revised Date:05/24/2019