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Test Name:Anti-mitochondrial antibody
Test Number:652
Collect:1.0 mL serum - SST
Peds Collect:0.3 mL serum - SST
Alternate Collect:1.0 mL serum - red
Container:Serum Separator (SST/Gold) or
AHL False Bottom Plasma/Serum Transport Tube
Processing:SST: spin
Red: spin and separate
Transport/Stability:Refrigerated (preferred) - 7 days
Frozen (OK)
Alternate Names:AMA
M2 Antibodies
86255.1
Performing Lab:AHL - Immunology; I
Days Set Up:1 - 2 times/wk (varies)
Expected TAT:1 - 8 days
Ref. Ranges:Negative (<1:20)
Collection/
Processing Details:
Anti-mitochondrial antibodies are present in 85 to 95 %t of cases of primary biliary cirrhosis. The presence of high titers of AMA is helpful in distinguishing biliary cirrhosis from liver problems due to obstruction outside of the liver, viral hepatitis, and alcoholic cirrhosis. Low titers may be detected in other liver disorders including chronic active hepatitis and cryptogenic cirrhosis.

Reflexes to titer if positive.

Screening perfomed at 1:20 dilution. Titers performed - 1:40, 80, 160, 320 and 640
Method:Indirect Fluorescent Antibody (IFA)
CPT Codes:86255
Date Created:11/30/2001
Revised Date:09/07/2018