Allina Health Laboratory a part of Abbott Northwestern Hospital



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Test Name:Paraneoplastic autoantibody evaluation
Test Number:8070
Collect:4.0 mL serum - red
Minimum Volume:2.0 mL serum - red
Container:Mayo Screw Cap Transfer Vial
Processing:Spin and separate
Transport/Stability:Refrigerated (preferred) - 28 days
Frozen - 28 days
Ambient: - 72 hours
Alternate Names:Calcium channel blockers
Hu Antibody
Isaacs Disease
Myoid Antibodies
Neuromucular Hyperexcitability
Paraneoplastic Ab
Purkinje cell cytoplasmic Abs
Ri, Anti
Stiff-man syndrome
Striational (Striated Muscle) Antibodies
Performing Lab:Mayo Clinic Laboratories (PAVAL/83380); R-MM
Days Set Up:Mo - Su
Expected TAT:10 - 17 days
Ref. Ranges:See Report
Processing Details:
Useful for:
- Serological evaluation of patients who present with a subacute neurological disorder of undetermined etiology, especially those with known risk factors for cancer
 - Directing a focused search for cancer
 - Investigating neurological symptoms that appear in the course of, or after, cancer therapy, and are not explainable by metastasis
 - Differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy
- Monitoring the immune response of seropositive patients in the course of cancer therapy
- Detecting early evidence of cancer recurrence in previously seropositive patients

All listed tests are included: Anti-Neuronal Nuclear Ab Type 1, Anti-Neuronal Nuclear Ab Type 2, Anti-Neuronal Nuclear Ab Type 3, Anti-Glial Nuclear Ab Type 1, Purkinje Cell Cytoplasmic Ab Type 1, Purkinje Cell Cytoplasmic Ab Type 2, Purkinje Cell Cytoplasmic Ab Type Tr, Amphiphysin Ab, CRMP-5-IgG, Striational (Striated Muscle) Ab, P/Q-Type Calcium Channel Ab, N-Type Calcium Channel Ab, ACh Receptor (Muscle) Binding Ab, AChR Ganglionic Neuronal Ab, Neuronal (V-G) K+ Channel Ab .

Reflex testing when indicated performed at an additional charge:
ACh Receptor (Muscle) Modulating Ab, Amphiphysin Western Blot, NMDA-R Ab CBA, AMPA-R Ab CBA, GABA-B-R Ab CBA, NMDA-R Ab IF Titer Assay, AMPA-R Ab IF Titer Assay, GABA-B-R Ab IF Titer Assay, NMO/AQP4 FACS, NMO/AQP4 FACS Titer, CRMP-5-IgG Western Blot, LGI1-IgG CBA, CASPR2-IgG CBA.
Method:Immunofluorescence Assay (IFA)
Enzyme Immunoassay (EIA)
Radioimmunoassay (RIA)
Western Blot and
Cell-binding assay (CBA)
Flow Cytometry
CPT Codes:83519- ACh receptor (muscle) binding Ab
83519- AChR ganglionic neuronal Ab
83519- Neuronal VGKC autoAb
83519- N-type calcium channel Ab
83519- P/Q-type calcium channel Ab
83520- Striational (striated muscle) Abs
86255- AGNA-1
86255- Amphiphysin
86255- ANNA-1
86255- ANNA-2
86255- ANNA-3
86255- CRMP-5-IgG
86255- PCA-1
86255- PCA-2
86255- PCA-Tr

Reflex Testing(if appropriate)
83519- ACh receptor (muscle) modulating Abs
84182- Amphiphysin WB
84182- CRMP-5-IgG WB
84182- Paraneoplastic autoantibody WB confirmation
86255- NMO/AQP4-IgG FACS
86255- AMPCS
86255- GABCS
86255- NMDCS
86256- AMPIS
86256- GABIS
86256- NMDIS
86256- NMO/AQP4-IgG FACS titer
86341- GAD65 Ab assay
86255- LG1CS
86255- CS2CS
Additional Information: Mayo Paraneoplastic Evaluation Algorithm
Date Created:06/10/2004
Revised Date:06/14/2019