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Test Name:ANCA Panel for Vasculitis
Test Number:528
Collect:1.0 mL Serum - SST
Alternate Collect:1.0 mL Serum - Plain Red
Heparinized plasma is not acceptable.
Container:Serum Separator (SST/Gold) tube or
AHL False Bottom Plasma/Serum Transport Tube
Processing:SST - Spin
Plain Red - Spin and separate
Transport/Stability:Refrigerated - 7 days
Alternate Names:Anti-neutropohil Cytoplasmic Antibodies
Vasculitis Panel
Cytoplasmic Neutrophilic Antibody
CNA
pANCA
p-ANC
c-ANCA
ANCA
LAB528
Performing Lab:AHL - Immunology; I
Days Set Up:Tu, Th
Expected TAT:3 - 5 days
Ref. Ranges:p-ANCA: Negative
c-ANCA: Negative
Collection/
Processing Details:
ANCA (anti-neutrophil cytoplasmic antibodies) occur in patients with granulomatosis with polyangitis (GPA), microscopic polyarteritis, necrotizing or crescentic glomerulonephritis, other vasculitides and inflammatory bowel disorders (primarily ulcerative colitis).
If c-ANCA Screen is positive, c-ANCA titer will be performed at an additional cost.

Screening performed at 1:20 dilution.
Titers performed for positive c-ANCA and p-ANCA at the following dilutions: 1:40, 80, 160, 320, 640, 1280. ANA will be performed at 1:20 on any Atypical p-ANCA to rule out interference. Note that ANA at this titer is utilized in the laboratory for interpretation only. It is not a reportable ANA result and should not be interpreted as a positive ANA for the diagnosis of lupus or other auto-immune disease.

Positive or atypical c-ANCA and p-ANCA will reflex to Myeloperoxidase Antibodies and Proteinase 3 Antibodies, IgG at an additional charge.
Method:Immunofluorescence Assay (IFA)
CPT Codes:86255 - ANCA
86256 - Titer (if indicated)
Clinical Utilities:
Date Created:07/30/2007
Revised Date:05/19/2017