ANCA (anti-neutrophil cytoplasmic antibodies) occur in patients with granulomatosis with polyangitis (GPA), microscopic polyarteritis, necrotizing or crescentic glomerulonephritis, other vasculitides and inflammatory bowel disorders (primarily ulcerative colitis).
If c-ANCA Screen is positive, c-ANCA titer will be performed at an additional cost.
Screening performed at 1:20 dilution.
Titers performed for positive c-ANCA and p-ANCA at the following dilutions:
1:40, 80, 160, 320, 640, 1280.
ANA will be performed at 1:20 on any Atypical p-ANCA to rule out interference. Note that ANA at this titer is utilized in the laboratory for interpretation only. It is not a reportable ANA result and should not be interpreted as a positive ANA for the diagnosis of lupus or other auto-immune disease.