Submit processed tissue block (preferred) or
3 unstained glass, "positively charged" slides with 4-microns formalin-fixed, paraffin-embedded tissue
Mayo Clinic Laboratories (PDL12); R
Days Set Up:
Mo - Fr
5 - 7 days
This test will be reported as percent tumor cells positive and whether greater than or equal to 5% of immune cells express programmed cell death 1-ligand 1 (PD-L1) or not. For gastric and gastroesophageal junctional adenocarcinoma, PD-L1 will be reported as combined positive score (CPS).
Collection/ Processing Details:
Identification of neoplasms expressing programmed cell death 1-ligand 1 (clone 22C3)
This test has been validated for nondecalcified paraffin-embedded tissue specimens fixed in 10% neutral-buffered formalin. This assay has not been validated on tissues subjected to the decalcification process or the use of alternative fixatives for bone and bone marrow specimens or cell blocks.
A pathology/diagnostic report and a brief history are required.
Immunohistochemistry on sections of paraffin-embedded tissue using Dako PD-L1 clone 22C3. (Unpublished Mayo method)