24 Hr Urine Conatiner + 25 mL 50 % Acetic Acid Submit 10 mL aliquot in 60 mL Mayo Urine Aliquot Bottle
Submit entire specimen or a 10 mL aliquot in a Mayo Urine Aliquot Bottle. 24-hr volume is required.
Refrigerated (preferred) - 28 days
Frozen (OK) - 28 days
Ambient (OK with preservative) - 14 days
Mayo Clinic Laboratories (ALDU); R-MM
Days Set Up:
Tu, Th; 1 p.m.
2 - 8 days
≥1 year: 2.0-20.0 µg/24 hr
Collection/ Processing Details:
Useful for the investigation of primary aldosteronism (eg, adrenal adenoma/carcinoma and adrenal cortical hyperplasia) and secondary aldosteronism (renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, Bartter syndrome)
Spironolactone (Aldactone) should be discontinued for 4 to 6 weeks before testing.
Add 25 mL 50% acetic acid at start of collection. Use 15 mL of 50% acetic acid for pediatric patients < 5 years old. Preservative is intended to achieve a pH of 2.0 - 4.0.
Record total volume of urineand preservative used on aliquot bottle. Alternate acceptable preservatives Aldosterone with Sodium is Mayo test ALDNA.
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)