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Test Name:PAX2 by IHC
Test Number:12376 - Technical only; 12379 - Technical & Interpretation
Collect:Formalin-fixed, paraffin embedded (FFPE) tissue block
Container:FFPE tissue block
Processing:Submit processed tissue block or tissue section mounted on a charged, unstained slide
Transport/Stability:Ambient (preferred)
Alternate Names:IHC
LAB12376
LAB12379
Performing Lab:AHL - Immunohistochemistry
Days Set Up:Mo - Fr
Expected TAT:1 - 2 days
Ref. Ranges:If requested, an interpretive report will be provided
All IHC stains will include a positive control tissue
Collection/
Processing Details:

Specifications:
  • The Pax genes are a family of transcription factors that are active in certain tissues during early embryogenesis
  • PAX2 expression is seen in developing kidney, and in Wilms' tumors
Staining pattern:
  • Nuclear
Applications:
  • PAX2 has been reported in 88% of conventional clear cell renal cell carcinomas
  • Papillary renal cell carcinomas and oncocytomas are also often positive for PAX2
  • PAX2 can be used in a panel with CK7, and KIT to assist with classification of tumor type1
  • Chromophobe renal cell carcinomas are usually negative for PAX2
  • PAX2 expression has been reported in 100% of nephrogenic adenomas (39/39)
  • PAX2 has not been identified in prostate tissue, urothelium, or invasive transitional carcinomas
  • PAX 2 also marks Mullerian epithelial structures, and has been identified in fallopian tube, endometrial and endocervical epithelium, as well as in endometriosis and endosalpingiosis
  • Sixty-seven percent of ovarian papillary serous carcinomas have also reportedly stained for PAX2
References:
  1. Memeo L et al: Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2; value in the differential diagnosis of chromophobe cell carcinoma.
  2. Mazal PR et al: Expression of aquaporins and PAX2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study.
  3. Tong GX et al: PAX2: a reliable marker for nephrogenic adenoma. Mod Pathol, 2006, Mar; 19(3):356-63.
  4. Tong GX et al: Expression of PAX2 in papillary serous carcinoma of the ovary; immunohistochemical evidence of fallopian tube or secondary Mullerian system origin? Mod Pathol 2007, Aug; 20(8):856-63.

Method:Immunohistochemical staining
Microscopic examination
CPT Codes:88342 - 1st stain
88341 - each additional stain
Date Created:08/07/2017
Revised Date:10/19/2018