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PAX2 by IHC
12376 - Technical only; 12379 - Technical & Interpretation
Formalin-fixed, paraffin embedded (FFPE) tissue block
FFPE tissue block
Submit processed tissue block or tissue section mounted on a charged, unstained slide
AHL - Immunohistochemistry
Days Set Up:
Mo - Fr
1 - 2 days
If requested, an interpretive report will be provided
All IHC stains will include a positive control tissue
The Pax genes are a family of transcription factors that are active in certain tissues during early embryogenesis
PAX2 expression is seen in developing kidney, and in Wilms' tumors
PAX2 has been reported in 88% of conventional clear cell renal cell carcinomas
Papillary renal cell carcinomas and oncocytomas are also often positive for PAX2
PAX2 can be used in a panel with CK7, and KIT to assist with classification of tumor type
Chromophobe renal cell carcinomas are usually negative for PAX2
PAX2 expression has been reported in 100% of nephrogenic adenomas (39/39)
PAX2 has not been identified in prostate tissue, urothelium, or invasive transitional carcinomas
PAX 2 also marks Mullerian epithelial structures, and has been identified in fallopian tube, endometrial and endocervical epithelium, as well as in endometriosis and endosalpingiosis
Sixty-seven percent of ovarian papillary serous carcinomas have also reportedly stained for PAX2
Memeo L et al: Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2; value in the differential diagnosis of chromophobe cell carcinoma.
Mazal PR et al: Expression of aquaporins and PAX2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study.
Tong GX et al: PAX2: a reliable marker for nephrogenic adenoma. Mod Pathol, 2006, Mar; 19(3):356-63.
Tong GX et al: Expression of PAX2 in papillary serous carcinoma of the ovary; immunohistochemical evidence of fallopian tube or secondary Mullerian system origin? Mod Pathol 2007, Aug; 20(8):856-63.
88342 - 1
88341 - each additional stain