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Test Name:Prostate health index (PHI), serum
Test Number:994
Collect:1.0 mL serum - red
Container:Mayo Screw Cap Transfer vial
Processing:Spin and separate and freeze within 3 hours of collection
Transport/Stability:Frozen - 150 days
Alternate Names:PHI
Prostate Health Index
Pro-2-PSA
PSA
4KScore
MSO
LAB994
Performing Lab:Mayo Clinic Laboratories (PHI11); R-NX
Days Set Up:Mo - Sa
Expected TAT:2 - 3 days
Ref. Ranges:See report

Testing Algorithm:
This test begins with the analysis of prostate-specific antigen (PSA). If the PSA is between 2.0 and 10.0 ng/mL, then the reflex test (PHI13) will be performed.

If the initial PSA is between 2.0 and 10.0 ng/mL, then free PSA and [-2]ProPSA will be reported.

If the initial PSA is between 4.0 and 10.0 ng/mL, then the percent free PSA and prostate health index (phi) will be calculated and reported.

If the initial PSA is between 2.0 and 4.0 ng/mL, then the percent free PSA and prostate health index (phi) will not be calculated or reported.
Collection/
Processing Details:
Useful for: Aids in distinguishing prostate cancer from benign prostate conditions in men with total prostate-specific antigen (PSA) concentrations in the 4 to 10 ng/mL range and digital rectal examination (DRE) findings that are not suspicious for cancer.

Patient Preparation:
  1. Specimens for testing should be drawn prior to prostate manipulations such as digital rectal examination (DRE), prostatic massage, transrectal ultrasound (TRUS), and prostatic biopsy.
  2. Specimens should not be collected from patients receiving therapy with high biotin (vitamin B7) doses (ie, >5 mg/day) until at least 8 hours following the last biotin administration.
Collection instructions:

Spin down within 3 hours of draw and separate serum from cells.
Method:Immunoenzymatic Assay
CPT Codes:84153
Date Created:07/19/2017
Revised Date:10/16/2018