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Cytogenetics laboratory

Director: Sung-Hae (Sue) Kang, PhD, FACMG

The Allina Health Cytogenetics Laboratory provides comprehensive testing services to detect chromosomal abnormalities for congenital disorders, prenatal diagnosis, hematologic malignancies and solid tumors. We are a full service Cytogenetics Laboratory with expertise in processing amniotic fluid, chorionic villi, products of conception, skin biopsy, peripheral blood (neonatal, pediatric, and adult), percutaneous umbilical blood (PUBS), leukemic blood, bone marrow, and malignant tissue specimens. All of our technical staff are certified in Cytogenetics. Our highly trained professional staff provides accurate, high quality results with excellent turn-around-times and exceptional customer service. We also partner with genetic counselors and pathologists to support the needs of our patients and providers.

Located in the central laboratory facility on the Abbott Northwestern Hospital campus in Minneapolis, we offer the full spectrum of Cytogenetic testing – chromosomal microarray (CMA)/ array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) and chromosome analyses. We process ~6000 specimens a year, making us one of the largest cytogenetics laboratories in the Midwest. We also serve as an international reference laboratory for outreach clients and participate in clinical research projects.

For more information please contact the Cytogenetics Laboratory at (612) 863-4541 or Client Services at (800) 281-4379.

Hours

Mon - Fri: 8am - 5pm
After hours: the lab is minimally staffed Mon-Fri until 11pm and Sat - Sun 8am - 4pm

Test List


CONGENITAL CYTOGENETIC TESTS
Chromosome studies

  • Prenatal Requires Maternal and Paternal blood specimens collected in EDTA tubes

Combination test – Limited Chromosome Study Plus Microarray (CMA) Analysis


CONGENITAL FISH TESTS
Aneuploidy Perinatal X/Y/13/18/21 Panel
Aneuploidy X/Y/18 ONLY Panel
Aneuploidy 13/21 ONLY Panel
Angelman syndrome (AS)15q11.2
Cri du Chat syndrome 5p15.2
DiGeorge/VCFS/CATCH22 (DGS)22q11.2
Kallmann syndrome Xp22.3
Miller-Dieker syndrome (MDS) 17p13.3
Prader-Willi syndrome (PWS) 15q11.2
Smith-Magenis syndrome (SMS) 17p11.2
Sotos syndrome 5q35
SRY Yp11.3
Steroid Sulfatase (STS) deficiency Xp22.3
Williams Beuren syndrome (WBS) 7q11.23
Wolf-Hirschhorn syndrome (WHS) 4p16.3
XIST Xq13.2

OTHER CONGENITAL SERVICES
Tissue Culture Only
Follow-up Parental / Family Studies
Sendout tests

ONCOLOGY CYTOGENETIC TESTS
Oncology Chromosomes

ONCOLOGY CYTOGENETIC FISH TESTS
5q31 deletion / Monosomy 5 (-5)
6q deletion
7q31 deletion / Monosomy 7 (-7)
Trisomy 8 (+8)
Trisomy 12 (+12)
13q14 deletion
20q12 deletion
Aneuploidy 4/10/17
ALK (non-morphometric) 2p23
API2/MALT1 t(11;18)
ATM deletion 11q22.3
BCL2 18q21
BCL2/IGH t(14;18)
BCL6 3q27
BCR/ABL1 t(9;22)
CBFB 16q22
CCND1/IGH t(11;14)
CCND3/IGH t(6;14)
CDKN2C (P18)/CKS1B 1p32.3/1q21
CHIC2/FIP1L1/PDGFRA 4q12
CRLF2 Xp22.3/Yp11.3
ETV6 (TEL) 12p13
ETV6/RUNX1 (TEL/AML1) t(12;21)
EWSR1 (non-morphometric) 22q12
FGFR1 8p12
FGFR3/IGH t(4;14)
IGH 14q32
IGH/MAF t(14;16)
IGH/MAFB t(14;20)
IGH/MALT1 t(14;18)
MALT1 18q21
MECOM 3q26.2
MLL 11q23
MYC 8q24
MYC/IGH t(8;14)
P16 (CDKN2A) deletion 9p21
PDGFRB 5q32
PML/RARA t(15;17)
RUNX1T1/RUNX1 (AML1/ETO) t(8;21)
SYT (SS18) (non-morphometric) 18q11.2
TCF3 19p13
TCL1 14q32
TCR (TRA/D) 14q11
TCRB 7q34
TP53 deletion 17p13.1

ONCOLOGY FISH PANELS

B Cell ALL Panel

  • BCR/ABL1 [t(9;22)], ETV6/RUNX1 [t(12;21)], MLL (11q23), Aneuploidy 4/10/17
  • Reflex to: IGH (14q32), CRLF2 (Xp22.3/Yp11.3)

T Cell ALL Panel

  • BCR/ABL1 [t(9;22)], P16 (CDKN2A) 9p21
  • Reflex to: TCR (TRA/D) 14q11.2, TCL1 (14q32), TCRB (7q34)

AML Panel (Follows COG protocol for AML)

  • BCR/ABL1 [t(9;22)], RUNX1T1/RUNX1 [t(8;21)], MLL (11q23), CBFB (16q22), 5q31 deletion/ -5, 7q31 deletion/ -7

CLL Panel

  • 6q deletion, ATM deletion (11q22.3), Trisomy 12, 13q14 deletion, TP53 deletion (17p13.1), CCND1/IGH [t(11;14)]

Eosinophilia Panel

  • BCR/ABL1 [t(9;22)], CHIC2-PDGFRA (4q12), PDGFRB (5q32), FGFR1 (8p12)

Lymphoma Panel

  • MYC (8q24), IGH/BCL2 [t(14;18)], BCL6 (3q27)

MDS Panel

  • 5q31 deletion / -5, 7q31 deletion / -7, Trisomy 8, MLL (11q23), 20q12 deletion

Myeloma Panel (with plasma cell enrichment)

  • CDKN2C/CKS1B (1p/q), 13q14 deletion/-13, TP53 (17p13.1), Aneuploidy 5, 7, 9, 11, 15
  • IGH (14q32) with reflex CCND1/IGH [t(11;14)], FGFR3/IGH [t(4;14)] IGH/MAF [t(14;16)], CCND3/IGH [t(6;14)], IGH/MAFB [t(14;20)]

ONCOLOGY MORPHOMETRIC/PATHOLOGY FISH TESTS
ALK Non-Small Cell Lung Cancer 2p23
CHOP (DDIT3) Myxoid Liposarcoma 12q13
EWSR1 Ewing Sarcoma 22q12
FOXO1 (FKHR) Rhabdomyosarcoma 13q14
FUS Fibromixoid Sarcoma 16p11.2
HER2/neu Breast and Gastric Cancer 17q12
MDM2 Liposarcoma 12q15
Oligodendroglioma Panel 1p36/19q13
SYT (SS18) Synovial Sarcoma 18q11.2
Urine Bladder Cancer Aneuploidy

Resources


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Allina Health Laboratory
Client Services
612-863-4678 or 1-800-281-4379
Fax: 612-863-4067
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